由上海交通大学医学院附属新华医院牵头开展的高循证级别、安慰剂随机对照双盲研究[9]证实,利巴韦林气雾剂治疗同为 EV 引起的手足口病,结果提示,用药 5~7 天后,利巴韦林气雾剂组 EV 总阴转率显著高于对照组,且总显效率和总有效率均高对照组,两组患者均无头晕、呕吐等不良反应发生,具有用药剂量小、疗效好、不良反应少的特点。
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[4]. Kim B,Moon S,Bae GR,et al.Factors associated with severe neurologic complications in patients with either hand-foot-mouth disease or herpangina: A nationwide observational study in South Korea, 2009-2014[J].PLoS One,2018,13(8):e0201726.
[8]. de Crom SC,Rossen JW,van Furth AM,et al. Enterovirus and parechovirus infection in children: a brief overview[J].Eur J Pediatr,2016,175(8):1023-1029.